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In depression paradigms, KOR signaling is responsive to a variety of stressors, and mediates despair-like responses. The KOR belongs to the opioid system, a neuromodulatory system that is widely expressed throughout the central and peripheral nervous systems. Current data suggest that the KOR modulates overlapping neuronal networks linking brainstem monoaminergic nuclei with forebrain limbic structures.

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  1. Unfortunately, early human studies exploring properties of KOR agonists reported potent dysphoric and psychomimetic effects 25 , When an ebony shows her black boobs, they have an allure which is only hard to explain.

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